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Gulls as Sources of Environmental Contamination by Colistin-resistant Bacteria.


ABSTRACT: In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug resistant bacterial infections in humans. Since then, mcr-1 was found in other human and animal populations, including wild gulls. Because gulls could disseminate the mcr-1 gene, we conducted an experiment to assess whether gulls are readily colonized with mcr-1 positive E. coli, their shedding patterns, transmission among conspecifics, and environmental deposition. Shedding of mcr-1 E. coli by small gull flocks followed a lognormal curve and gulls shed one strain >101 log10 CFU/g in their feces for 16.4 days, which persisted in the environment for 29.3 days. Because gulls are mobile and can shed antimicrobial-resistant bacteria for extended periods, gulls may facilitate transmission of mcr-1 positive E. coli to humans and livestock through fecal contamination of water, public areas and agricultural operations.

SUBMITTER: Franklin AB 

PROVIDER: S-EPMC7064522 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Gulls as Sources of Environmental Contamination by Colistin-resistant Bacteria.

Franklin Alan B AB   Ramey Andrew M AM   Bentler Kevin T KT   Barrett Nicole L NL   McCurdy Loredana M LM   Ahlstrom Christina A CA   Bonnedahl Jonas J   Shriner Susan A SA   Chandler Jeffrey C JC  

Scientific reports 20200310 1


In 2015, the mcr-1 gene was discovered in Escherichia coli in domestic swine in China that conferred resistance to colistin, an antibiotic of last resort used in treating multi-drug resistant bacterial infections in humans. Since then, mcr-1 was found in other human and animal populations, including wild gulls. Because gulls could disseminate the mcr-1 gene, we conducted an experiment to assess whether gulls are readily colonized with mcr-1 positive E. coli, their shedding patterns, transmission  ...[more]

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