Size-Dependent Cellular Uptake of RGD Peptides.
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ABSTRACT:
SUBMITTER: Kemker I
PROVIDER: S-EPMC7064889 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
Size-Dependent Cellular Uptake of RGD Peptides.
Kemker Isabell I Feiner Rebecca C RC Müller Kristian M KM Sewald Norbert N
Chembiochem : a European journal of chemical biology 20191025 4
Monomeric RGD peptides show unspecific fluid-phase uptake in cells, whereas multimeric RGD peptides are thought to be internalized by integrin-mediated endocytosis. However, a potential correlation between uptake mechanism and molecular mass has been neglected so far. A dual derivatization of peptide c(RGDw(7Br)K) was performed to investigate this. A fluorescent probe was installed by chemoselective Suzuki-Miyaura cross-coupling of the 7-bromotryptophan and a poly(ethylene glycol) (PEG) linker w ...[more]
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