Ontology highlight
ABSTRACT:
SUBMITTER: Bendickova K
PROVIDER: S-EPMC7064969 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Bendíčková Kamila K Tidu Federico F De Zuani Marco M Kohoutková Marcela Hortová MH Andrejčinová Ivana I Pompeiano Antonio A Bělášková Silvie S Forte Giancarlo G Zelante Teresa T Frič Jan J
Journal of leukocyte biology 20190401 3
Calcineurin (CN) inhibitors are effective clinical immunosuppressants but leave patients vulnerable to potentially fatal fungal infections. This study tested the hypothesis that CN inhibition interferes with antifungal immune defenses mediated by monocytes. We showed that NFAT is expressed by human monocytes, and is activated by exposure to fungal ligands. We confirmed that NFAT translocation potently activated target gene transcription using a human monocytic reporter cell line. Inhibition of C ...[more]