Ontology highlight
ABSTRACT:
SUBMITTER: Zhu Q
PROVIDER: S-EPMC7065147 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Zhu Qianqian Q Zhang Jianmin J Chen Yanmin Y Hu Qiang Q Shen He H Huang Ruea-Yea RY Liu Qian Q Kaur Jasmine J Long Mark M Battaglia Sebastiano S Eng Kevin H KH Lele Shashikant B SB Zsiros Emese E Villella Jeannine J Lugade Amit A Yao Song S Liu Song S Moysich Kirsten K Odunsi Kunle O KO
International journal of cancer 20190716 8
Despite the identification of several ovarian cancer (OC) predisposition genes, a large proportion of familial OC risk remains unexplained. We adopted a two-stage design to identify new OC predisposition genes. We first carried out a large germline whole-exome sequencing study on 158 patients from 140 families with significant OC history, but without evidence of genetic predisposition due to BRCA1/2. We then evaluated the potential candidate genes in a large case-control association study involv ...[more]