Ontology highlight
ABSTRACT:
SUBMITTER: Grunberger G
PROVIDER: S-EPMC7065168 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Grunberger George G Bhargava Anuj A Ly Trang T Zisser Howard H Ilag Liza L LL Malone James J Fan Ludi L Zhang Shuyu S Johnson Jennal J
Diabetes, obesity & metabolism 20200126 3
<h4>Aim</h4>To compare the safety and efficacy of U500-R delivered by a novel, specifically designed U500-R insulin pump with U-500R delivered by multiple daily injections (MDI).<h4>Methods</h4>The phase 3 VIVID study randomized people with type 2 diabetes to U-500R by continuous subcutaneous insulin infusion (CSII) or MDI. Participants (aged 18-85 years) had HbA1c ≥7.5% and ≤12.0% and a total daily dose of insulin >200 and ≤600 U/day. After a 2-week transition to three times daily injections of ...[more]