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A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile.


ABSTRACT: The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (RORC) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead-based assay using the Bio-Plex MAGPIX system, and RORC mRNA expression was determined by quantitative polymerase chain reaction (qPCR). As a result, significant differences in IL-31 were observed between study groups (77.23?pg/mL in PsA vs 64.4?pg/mL in CS, P?

SUBMITTER: Bautista-Herrera LA 

PROVIDER: S-EPMC7065432 | biostudies-literature | 2020 Jan-Dec

REPOSITORIES: biostudies-literature

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A potential inflammatory role of IL-31 in psoriatic arthritis: A correlation with Th17 cytokine profile.

Bautista-Herrera L A LA   De la Cruz-Mosso U U   Román-Fernández I V IV   Parra-Rojas I I   Soñanez-Organis J G JG   Hernández-Bello J J   Morales-Zambrano R A RA   Villanueva-Quintero G D GD   Muñoz-Valle J F JF  

International journal of immunopathology and pharmacology 20200101


The goals of our study were to determine the possible association of interleukin (IL)-31 with Th17 cytokine profile in serum and to quantify retinoic acid-related orphan receptor C (<i>RORC</i>) mRNA expression in psoriatic arthritis (PsA) patients. This cross-sectional study was conducted in 50 patients with PsA and 30 control subjects (CS) matched by age and gender. The cytokine serum levels were quantified by magnetic bead-based assay using the Bio-Plex MAGPIX system, and <i>RORC</i> mRNA exp  ...[more]

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