Ontology highlight
ABSTRACT:
SUBMITTER: Bolivar BE
PROVIDER: S-EPMC7065599 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Bolívar Beatriz E BE Vogel Tiphanie P TP Bouchier-Hayes Lisa L
The FEBS journal 20190527 14
Members of the mammalian inflammatory caspase family, including caspase-1, caspase-4, caspase-5, caspase-11, and caspase-12, are key regulators of the innate immune response. Most studies to date have focused on the role of caspase-1 in the maturation of the proinflammatory cytokine interleukin-1β and its upstream regulation by the inflammasome signaling complexes. However, an emerging body of research has supported a role for caspase-4, caspase-5, and caspase-11 in both regulating caspase-1 act ...[more]