Ontology highlight
ABSTRACT:
SUBMITTER: Yoon MK
PROVIDER: S-EPMC7065656 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Yoon Mi-Kyung MK Mitrea Diana M DM Ou Li L Kriwacki Richard W RW
Biochemical Society transactions 20121001 5
Today, it is widely accepted that proteins that lack highly defined globular three-dimensional structures, termed IDPs (intrinsically disordered proteins), play key roles in myriad biological processes. Our understanding of how intrinsic disorder mediates biological function is, however, incomplete. In the present paper, we review disorder-mediated cell cycle regulation by two intrinsically disordered proteins, p21 and p27. A structural adaptation mechanism involving a stretchable dynamic linker ...[more]