The cell cycle in stem cell proliferation, pluripotency and differentiation.
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ABSTRACT:
SUBMITTER: Liu L
PROVIDER: S-EPMC7065707 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Publications
The cell cycle in stem cell proliferation, pluripotency and differentiation.
Liu Lijun L Michowski Wojciech W Kolodziejczyk Aleksandra A Sicinski Piotr P
Nature cell biology 20190902 9
Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our current knowledge of how cell cycle proteins mechanistically link cell proliferation, pluripotency and cell fate specification. We focus on embryonic stem cells, induced pluripotent stem cells and embryoni ...[more]
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