Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
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ABSTRACT:
SUBMITTER: Hulme H
PROVIDER: S-EPMC7065903 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Microbiome-derived carnitine mimics as previously unknown mediators of gut-brain axis communication.
Hulme Heather H Meikle Lynsey M LM Strittmatter Nicole N van der Hooft Justin J J JJJ Swales John J Bragg Ryan A RA Villar Victor H VH Ormsby Michael J MJ Barnes Stephanie S Brown Sheila L SL Dexter Alex A Kamat Maya T MT Komen Jasper C JC Walker Daniel D Milling Simon S Osterweil Emily K EK MacDonald Andrew S AS Schofield Chris J CJ Tardito Saverio S Bunch Josephine J Douce Gillian G Edgar Julia M JM Edrada-Ebel RuAngelie R Goodwin Richard J A RJA Burchmore Richard R Wall Daniel M DM
Science advances 20200311 11
Alterations to the gut microbiome are associated with various neurological diseases, yet evidence of causality and identity of microbiome-derived compounds that mediate gut-brain axis interaction remain elusive. Here, we identify two previously unknown bacterial metabolites 3-methyl-4-(trimethylammonio)butanoate and 4-(trimethylammonio)pentanoate, structural analogs of carnitine that are present in both gut and brain of specific pathogen-free mice but absent in germ-free mice. We demonstrate tha ...[more]
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