Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.
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ABSTRACT:
SUBMITTER: Liu APY
PROVIDER: S-EPMC7065912 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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Risk-adapted therapy and biological heterogeneity in pineoblastoma: integrated clinico-pathological analysis from the prospective, multi-center SJMB03 and SJYC07 trials.
Liu Anthony P Y APY Gudenas Brian B Lin Tong T Orr Brent A BA Klimo Paul P Kumar Rahul R Bouffet Eric E Gururangan Sridharan S Crawford John R JR Kellie Stewart J SJ Chintagumpala Murali M Fisher Michael J MJ Bowers Daniel C DC Hassall Tim T Indelicato Daniel J DJ Onar-Thomas Arzu A Ellison David W DW Boop Frederick A FA Merchant Thomas E TE Robinson Giles W GW Northcott Paul A PA Gajjar Amar A
Acta neuropathologica 20191204 2
Pineoblastoma is a rare embryonal tumor of childhood that is conventionally treated with high-dose craniospinal irradiation (CSI). Multi-dimensional molecular evaluation of pineoblastoma and associated intertumoral heterogeneity is lacking. Herein, we report outcomes and molecular features of children with pineoblastoma from two multi-center, risk-adapted trials (SJMB03 for patients ≥ 3 years; SJYC07 for patients < 3 years) complemented by a non-protocol institutional cohort. The clinical cohort ...[more]
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