Ontology highlight
ABSTRACT:
SUBMITTER: Stotesbury C
PROVIDER: S-EPMC7065959 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Stotesbury Colby C Alves-Peixoto Pedro P Montoya Brian B Ferez Maria M Nair Savita S Snyder Christopher M CM Zhang Shunchuan S Knudson Cory J CJ Sigal Luis J LJ
Journal of immunology (Baltimore, Md. : 1950) 20200203 6
NK cells play an important role in antiviral resistance. The integrin α2, which dimerizes with integrin β1, distinguishes NK cells from innate lymphoid cells 1 and other leukocytes. Despite its use as an NK cell marker, little is known about the role of α2β1 in NK cell biology. In this study, we show that in mice α2β1 deficiency does not alter the balance of NK cell/ innate lymphoid cell 1 generation and slightly decreases the number of NK cells in the bone marrow and spleen without affecting NK ...[more]