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Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.

ABSTRACT: The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron production may continue for decades in humans.

SUBMITTER: Durante MA 

PROVIDER: S-EPMC7065961 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Single-cell analysis of olfactory neurogenesis and differentiation in adult humans.

Durante Michael A MA   Kurtenbach Stefan S   Sargi Zoukaa B ZB   Harbour J William JW   Choi Rhea R   Kurtenbach Sarah S   Goss Garrett M GM   Matsunami Hiroaki H   Goldstein Bradley J BJ  

Nature neuroscience 20200217 3

The presence of active neurogenic niches in adult humans is controversial. We focused attention to the human olfactory neuroepithelium, an extracranial site supplying input to the olfactory bulbs of the brain. Using single-cell RNA sequencing analyzing 28,726 cells, we identified neural stem cell and neural progenitor cell pools and neurons. Additionally, we detailed the expression of 140 olfactory receptors. These data from the olfactory neuroepithelium niche provide evidence that neuron produc  ...[more]

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