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Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining.


ABSTRACT: Objective: Cancer is expected to be the leading cause of death worldwide within the 21st century and is the single most important obstacle to extending life expectancy. Unfortunately, the most effective approach to combating cancers remains a complex and unsolved problem. Siglec-15 is a member of the Siglec family and plays a conserved regulatory role in the immune system of vertebrates. Previous studies on Siglec-15 have focused on its function in osteoclast regulation. The purpose of this study was to explore the significance of Siglec-15 mRNA in human cancer mainly based on information obtained from online databases. Method: Data were collected from several online databases. Serial analysis of gene expression (SAGE) and Virtual Northern, UALCAN Database Analysis, Catalog of Somatic Mutations in Cancer (COSMIC) analysis, the cBio cancer genomics portal, Cancer Regulome tools and data, Kaplan-Meier Plotter Analysis and the UCSC Xena website were used to analyze the data. Results: Compared with normal tissues, Siglec-15 up-regulation was widely observed in tuomrs. Differences in Siglec-15 expression were associated with different prognoses. Siglec-15 mutations are widely observed in tumors and interact with different genes in different cancer types. Conclusion: Siglec-15 is a potential target for the expansion of cancer immunotherapy.

SUBMITTER: Li QT 

PROVIDER: S-EPMC7066007 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Integrative Analysis of Siglec-15 mRNA in Human Cancers Based on Data Mining.

Li Qiu-Ting QT   Huang Zao-Zao ZZ   Chen Yao-Bin YB   Yao Hong-Yi HY   Ke Zun-Hui ZH   He Xiao-Xiao XX   Qiu Meng-Jun MJ   Wang Meng-Meng MM   Xiong Zhi-Fan ZF   Yang Sheng-Li SL  

Journal of Cancer 20200210 9


<b>Objective</b>: Cancer is expected to be the leading cause of death worldwide within the 21st century and is the single most important obstacle to extending life expectancy. Unfortunately, the most effective approach to combating cancers remains a complex and unsolved problem. Siglec-15 is a member of the Siglec family and plays a conserved regulatory role in the immune system of vertebrates. Previous studies on Siglec-15 have focused on its function in osteoclast regulation. The purpose of th  ...[more]

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