Nintedanib ameliorates animal model of dermatitis.
Ontology highlight
ABSTRACT:
SUBMITTER: Heo MJ
PROVIDER: S-EPMC7066145 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Nintedanib ameliorates animal model of dermatitis.
Heo Min-Jeong MJ Lee Chanmi C Choi Soo Young SY Choi Yeong Min YM An In-Sook IS Bae Seunghee S An Sungkwan S Jung Jin Hyuk JH
Scientific reports 20200311 1
Nintedanib, a receptor tyrosine kinase (RTK) inhibitor has been developed as therapeutics for idiopathic pulmonary fibrosis and non-small lung cancer. We found that the expression levels of RTK, especially VEGFR1 is increased in skin biopsies of dermatitis patients from multiple independent datasets. Moreover, VEGFR1 is highly expressed by infiltrated cells in dermis from oxazolone (OXA) treated mice. Interestingly, nintedanib alleviates dermatitis symptom in OXA-induced animal model. Especially ...[more]
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