Dataset Information

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.

ABSTRACT:

Introduction

Infections could contribute to Alzheimer's disease (AD) neuropathology in human. However, experimental evidence for a causal relationship between infections during the prenatal phase and the onset of AD is lacking.

Methods

CD-1 mothers were intraperitoneally received lipopolysaccharide (LPS) with two doses (25 and 50 ?g/kg) or normal saline every day during gestational days 15-17. A battery of behavioral tasks was used to assess the species-typical behavior, sensorimotor capacity, anxiety, locomotor activity, recognition memory, and spatial learning and memory in 1-, 6-, 12-, 18-, and 22-month-old offspring mice. An immunohistochemical technology was performed to detect neuropathological indicators consisting of amyloid-? (A?), phosphorylated tau (p-tau), and glial fibrillary acidic protein (GFAP) in the hippocampus.

Results

Compared to the same-aged controls, LPS-treated offspring had similar behavioral abilities and the levels of A?42, p-tau, and GFAP at 1 and 6 months old. From 12 months onward, LPS-treated offspring gradually showed decreased species-typical behavior, sensorimotor ability, locomotor activity, recognition memory, and spatial learning and memory, and increased anxieties and the levels of A?42, p-tau, and GFAP relative to the same-aged controls. Moreover, this damage effect (especially cognitive decline) persistently progressed onwards. The changes in these neuropathological indicators significantly correlated with impaired spatial learning and memory.

Conclusions

Prenatal exposure to low doses of LPS caused AD-related features including behavioral and neuropathological changes from midlife to senectitude.

SUBMITTER: Wang F

PROVIDER: S-EPMC7066339 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Publications

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.

Wang Fang F Zhang Zhe-Zhe ZZ Cao Lei L Yang Qi-Gang QG Lu Qing-Fang QF Chen Gui-Hai GH

Brain and behavior 20200130 3

<h4>Introduction</h4>Infections could contribute to Alzheimer's disease (AD) neuropathology in human. However, experimental evidence for a causal relationship between infections during the prenatal phase and the onset of AD is lacking.<h4>Methods</h4>CD-1 mothers were intraperitoneally received lipopolysaccharide (LPS) with two doses (25 and 50 μg/kg) or normal saline every day during gestational days 15-17. A battery of behavioral tasks was used to assess the species-typical behavior, sensorimo ...[more]

PMID: 31997558

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Dataset Information

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.

Introduction

Methods

Results

Conclusions

Publications

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer-like behavioral and neuropathological changes in CD-1 mice.

Similar Datasets

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