Ontology highlight
ABSTRACT:
SUBMITTER: Nguyen HM
PROVIDER: S-EPMC7066416 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Nguyen Hannah My-Hanh HM Torres Jaclene Amber JA Agrawal Sudhanshu S Agrawal Anshu A
Mediators of inflammation 20200229
Smoking is a major risk factor for pulmonary diseases that include chronic obstructive pulmonary diseases (COPD) and cancer. Nicotine is the toxic and addictive component of tobacco products, like cigarettes, that negatively affects the immune system. Here, we examined the effect of nicotine on the IL-22 pathway that protects lung function by increasing transepithelial resistance and epithelial cell regeneration and repair. Our results indicate that exposure to nicotine impairs the regenerative ...[more]