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Long non-coding RNAs regulate drug resistance in cancer.

ABSTRACT: Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance.

SUBMITTER: Liu K

PROVIDER: S-EPMC7066752 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Long non-coding RNAs regulate drug resistance in cancer.

Liu Kaisheng K Gao Lin L Ma Xiaoshi X Huang Juan-Juan JJ Chen Juan J Zeng Leli L Ashby Charles R CR Zou Chang C Chen Zhe-Sheng ZS

Molecular cancer 20200312 1

Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various mechanisms. Over the last decade, it has been reported that 1ong noncoding RNAs (lncRNAs) can mediate carcinogenesis and drug resistance/sensitivity in cancer cells. This article reviews, in detail, recent studies regarding the roles of lncRNAs in mediating drug resistance. ...[more]

PMID: 32164712

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