Ontology highlight
ABSTRACT:
SUBMITTER: Gifford FJ
PROVIDER: S-EPMC7066808 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Gifford Fiona J FJ Dunne Philip D J PDJ Weir Graeme G Ireland Hamish H Graham Catriona C Tuck Sharon S Hayes Peter C PC Fallowfield Jonathan A JA
Trials 20200312 1
<h4>Background</h4>In preclinical models, recombinant human relaxin-2 (serelaxin) had anti-fibrotic effects and ameliorated portal hypertension (PH). A small exploratory study in patients with cirrhosis also suggested that serelaxin could reduce portal pressure.<h4>Methods</h4>In a phase 2, double-blind, randomised controlled study conducted in a single centre (Royal Infirmary of Edinburgh, UK), male and female adult participants with cirrhosis and clinically significant PH (CSPH; hepatic venous ...[more]