Ontology highlight
ABSTRACT:
SUBMITTER: Tian S
PROVIDER: S-EPMC7066881 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tian Shan S Peng Pailan P Li Jiao J Deng Huan H Zhan Na N Zeng Zhi Z Dong Weiguo W
Aging 20200224 4
In this study, we investigated the role of SERPINH1 in gastric cancer (GC) progression. GC patient tissues show significantly higher SERPINH1 mRNA and protein levels than normal gastric mucosal tissues. GC patients with high SERPINH1 expression are associated with lymph node metastasis and poor prognosis. SERPINH1 mRNA levels negatively correlate with E-cadherin mRNA levels and positively correlate with levels of N-cadherin, MMP2, and MMP9 mRNA levels. This suggests SERPINH1 regulates epithelial ...[more]