Ontology highlight
ABSTRACT:
SUBMITTER: Saik NO
PROVIDER: S-EPMC7067905 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Saik Natasha O NO Park Nogi N Ptak Christopher C Adames Neil N Aitchison John D JD Wozniak Richard W RW
Frontiers in genetics 20200306
In addition to their role in regulating transport across the nuclear envelope, increasing evidence suggests nuclear pore complexes (NPCs) function in regulating gene expression. For example, the induction of certain genes (e.g., yeast <i>INO1</i>) is accompanied by their movement from the nuclear interior to NPCs. As sumoylation has been linked to the regulation of chromatin spatial organization and transcriptional activity, we investigated the role of sumoylation in the expression and NPC recru ...[more]