Dataset Information

Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in Tibet.

ABSTRACT: BACKGROUND:Studies from both humans and animals experiments have offered abundant evidence supporting that mountain sickness is associated with changes in autonomic nervous function (ANF), which can be measured by heart rate variability (HRV). HYPOTHESIS:We aimed to assess changes of ANF in chronic mountain disease by measuring HRV in patients with high altitude pulmonary hypertension (HAPH). METHODS:From November 2018 to March 2019, 120 patients in the cardiac care unit of the People's Hospital of Tibet Autonomous Region were selected as the observation group, and 50 patients without organic heart disease served as the control group. Pulmonary artery systolic pressure was evaluated by echocardiography in patients with HAPH, divided into three groups: mild (30-49?mm Hg), moderate (50-69?mm Hg) and severity (?70?mm Hg) groups. A 24-hour dynamic electrocardiogram (DCG) was obtained for each patient. HRV (SDNN, SDANN, RMSSD, PNN50, and HRVTI for time domain; TP, VLF, LF, HF, and LF/HF for frequency domain) indexes were measured and compared. RESULTS:Compared with the control group, time domain parameters including SDNN, SDANN, RMSSD, PNN50, and HRVTI were reduced, as well as frequency domain indexes such as TP, VLF, LF, and HF. LF/HF was highest in mild HAPH group and lowest in the moderate HAPH group, and the difference between the two groups was statistically significant. CONCLUSIONS:The HRV of patients with chronic HAPH in high altitude areas in Tibet is significantly reduced relative to healthy controls, and significantly negatively correlated with the severity of pulmonary artery hypertension.

SUBMITTER: Qian Z

PROVIDER: S-EPMC7068065 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in Tibet.

Qian Zhang Z Fan Aili A Dawa Dawaciren Pan Binbin B

Clinical cardiology 20191219 3

<h4>Background</h4>Studies from both humans and animals experiments have offered abundant evidence supporting that mountain sickness is associated with changes in autonomic nervous function (ANF), which can be measured by heart rate variability (HRV).<h4>Hypothesis</h4>We aimed to assess changes of ANF in chronic mountain disease by measuring HRV in patients with high altitude pulmonary hypertension (HAPH).<h4>Methods</h4>From November 2018 to March 2019, 120 patients in the cardiac care unit of ...[more]

PMID: 31854019

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Project description:IntroductionHypertension is a leading cause of cardiovascular disease, which is the cause of one-third of global deaths and is a primary and rising contributor to the global disease burden. The objective of this systematic review was to determine the prevalence and awareness of hypertension among the inhabitants of Tibet and its association with altitude, using the data from published observational studies.MethodsWe conducted electronic searches in Medline, Embase, ISI Web of Science and Global Health. No gender or language restrictions were imposed. We assessed the methodological characteristics of included studies using the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) criteria. Two reviewers independently determined the eligibility of studies, assessed the methodology of included studies and extracted the data. We used meta-regression to estimate the degree of change in hypertension prevalence with increasing altitude.ResultsWe identified 22 eligible articles of which eight cross-sectional studies with a total of 16 913 participants were included. The prevalence of hypertension ranged between 23% and 56%. A scatter plot of altitude against overall prevalence revealed a statistically significant correlation (r=0.68; p=0.04). Meta-regression analysis revealed a 2% increase in the prevalence of hypertension with every 100 m increase in altitude (p=0.06). The locations and socioeconomic status of subjects affected the awareness and subsequent treatment and control of hypertension.ConclusionsThe results from cross-sectional studies suggest that there is a significant correlation between altitude and the prevalence of hypertension among inhabitants of Tibet. The socioeconomic status of the inhabitants can influence awareness and management of hypertension. Very little research into hypertension has been conducted in other prefectures of Tibet where the altitude is much higher. Further research examining the impact of altitude on blood pressure is warranted.

Dataset Information

Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in Tibet.

Publications

Retrospective cohort analysis of heart rate variability in patients with high altitude pulmonary hypertension in Tibet.

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