Dataset Information

Using Machine-Learning Algorithms for Eutrophication Modeling: Case Study of Mar Menor Lagoon (Spain).

ABSTRACT: The Mar Menor is a hypersaline coastal lagoon with high environmental value and a characteristic example of a highly anthropized hydro-ecosystem located in the southeast of Spain. An unprecedented eutrophication crisis in 2016 and 2019 with abrupt changes in the quality of its waters caused a great social alarm. Understanding and modeling the level of a eutrophication indicator, such as chlorophyll-a (Chl-a), benefits the management of this complex system. In this study, we investigate the potential machine learning (ML) methods to predict the level of Chl-a. Particularly, Multilayer Neural Networks (MLNNs) and Support Vector Regressions (SVRs) are evaluated using as a target dataset information of up to nine different water quality parameters. The most relevant input combinations were extracted using wrapper feature selection methods which simplified the structure of the model, resulting in a more accurate and efficient procedure. Although the performance in the validation phase showed that SVR models obtained better results than MLNNs, experimental results indicated that both ML algorithms provide satisfactory results in the prediction of Chl-a concentration, reaching up to 0.7 R2CV (cross-validated coefficient of determination) for the best-fit models.

SUBMITTER: Jimeno-Saez P

PROVIDER: S-EPMC7068380 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Using Machine-Learning Algorithms for Eutrophication Modeling: Case Study of Mar Menor Lagoon (Spain).

Jimeno-Sáez Patricia P Senent-Aparicio Javier J Cecilia José M JM Pérez-Sánchez Julio J

International journal of environmental research and public health 20200213 4

The Mar Menor is a hypersaline coastal lagoon with high environmental value and a characteristic example of a highly anthropized hydro-ecosystem located in the southeast of Spain. An unprecedented eutrophication crisis in 2016 and 2019 with abrupt changes in the quality of its waters caused a great social alarm. Understanding and modeling the level of a eutrophication indicator, such as chlorophyll-a (Chl-a), benefits the management of this complex system. In this study, we investigate the poten ...[more]

PMID: 32069834

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Project description:BackgroundEarly unplanned hospital readmissions are associated with increased harm to patients, increased medical costs, and negative hospital reputation. With the identification of at-risk patients, a crucial step toward improving care, appropriate interventions can be adopted to prevent readmission. This study aimed to build machine learning models to predict 14-day unplanned readmissions.MethodsWe conducted a retrospective cohort study on 37,091 consecutive hospitalized adult patients with 55,933 discharges between September 1, 2018, and August 31, 2019, in an 1193-bed university hospital. Patients who were aged < 20 years, were admitted for cancer-related treatment, participated in clinical trial, were discharged against medical advice, died during admission, or lived abroad were excluded. Predictors for analysis included 7 categories of variables extracted from hospital's medical record dataset. In total, four machine learning algorithms, namely logistic regression, random forest, extreme gradient boosting, and categorical boosting, were used to build classifiers for prediction. The performance of prediction models for 14-day unplanned readmission risk was evaluated using precision, recall, F1-score, area under the receiver operating characteristic curve (AUROC), and area under the precision-recall curve (AUPRC).ResultsIn total, 24,722 patients were included for the analysis. The mean age of the cohort was 57.34 ± 18.13 years. The 14-day unplanned readmission rate was 1.22%. Among the 4 machine learning algorithms selected, Catboost had the best average performance in fivefold cross-validation (precision: 0.9377, recall: 0.5333, F1-score: 0.6780, AUROC: 0.9903, and AUPRC: 0.7515). After incorporating 21 most influential features in the Catboost model, its performance improved (precision: 0.9470, recall: 0.5600, F1-score: 0.7010, AUROC: 0.9909, and AUPRC: 0.7711).ConclusionsOur models reliably predicted 14-day unplanned readmissions and were explainable. They can be used to identify patients with a high risk of unplanned readmission based on influential features, particularly features related to diagnoses. The operation of the models with physiological indicators also corresponded to clinical experience and literature. Identifying patients at high risk with these models can enable early discharge planning and transitional care to prevent readmissions. Further studies should include additional features that may enable further sensitivity in identifying patients at a risk of early unplanned readmissions.

Project description:Background:Hospital readmission prediction in pediatric hospitals has received little attention. Studies have focused on the readmission frequency analysis stratified by disease and demographic/geographic characteristics but there are no predictive modeling approaches, which may be useful to identify preventable readmissions that constitute a major portion of the cost attributed to readmissions. Objective:To assess the all-cause readmission predictive performance achieved by machine learning techniques in the emergency department of a pediatric hospital in Santiago, Chile. Materials:An all-cause admissions dataset has been collected along six consecutive years in a pediatric hospital in Santiago, Chile. The variables collected are the same used for the determination of the child's treatment administrative cost. Methods:Retrospective predictive analysis of 30-day readmission was formulated as a binary classification problem. We report classification results achieved with various model building approaches after data curation and preprocessing for correction of class imbalance. We compute repeated cross-validation (RCV) with decreasing number of folders to assess performance and sensitivity to effect of imbalance in the test set and training set size. Results:Increase in recall due to SMOTE class imbalance correction is large and statistically significant. The Naive Bayes (NB) approach achieves the best AUC (0.65); however the shallow multilayer perceptron has the best PPV and f-score (5.6 and 10.2, resp.). The NB and support vector machines (SVM) give comparable results if we consider AUC, PPV, and f-score ranking for all RCV experiments. High recall of deep multilayer perceptron is due to high false positive ratio. There is no detectable effect of the number of folds in the RCV on the predictive performance of the algorithms. Conclusions:We recommend the use of Naive Bayes (NB) with Gaussian distribution model as the most robust modeling approach for pediatric readmission prediction, achieving the best results across all training dataset sizes. The results show that the approach could be applied to detect preventable readmissions.

Project description:Background:Epilepsy is a disorder that can manifest as abnormalities in neurological or physical function. Stress cardiomyopathy is closely associated with neurological stimulation. However, the mechanisms underlying the interrelationship between epilepsy and stress cardiomyopathy are unclear. This paper aims to explore the genetic features and potential molecular mechanisms shared in epilepsy and stress cardiomyopathy. Methods:By analyzing the epilepsy dataset and stress cardiomyopathy dataset separately, the intersection of the two disease co-expressed differential genes is obtained, the co-expressed differential genes reveal the biological functions, the network is constructed, and the core modules are identified to reveal the interaction mechanism, the co-expressed genes with diagnostic validity are screened by machine learning algorithms, and the co-expressed genes are validated in parallel on the epilepsy single-cell data and the stress cardiomyopathy rat model. Results: Epilepsy causes stress cardiomyopathy, and its key pathways are Complement and coagulation cascades, HIF-1 signaling pathway, its key co-expressed genes include SPOCK2, CTSZ, HLA-DMB, ALDOA, SFRP1, ERBB3.The key immune cell subpopulations localized by single-cell data are the T_cells subgroup, Microglia subgroup, Macrophage subgroup, Astrocyte subgroup, and Oligodendrocytes subgroup. Conclusion: We believe epilepsy causing stress cardiomyopathy results from a multi-gene, multi-pathway combination. We identified the core co-expressed genes (SPOCK2, CTSZ, HLA-DMB, ALDOA, SFRP1, ERBB3) and the pathways that function in them (Complement and coagulation cascades, HIF-1 signaling pathway,JAK-STAT signaling pathway), and finally localized their key cellular subgroups(T_cells subgroup, Microglia subgroup, Macrophage subgroup, Astrocyte subgroup,and Oligodendrocytes subgroup). Also, combining cell subpopulations with hypercoagulability as well as sympathetic excitation further narrowed the cell subpopulations of related functions.

Dataset Information

Using Machine-Learning Algorithms for Eutrophication Modeling: Case Study of Mar Menor Lagoon (Spain).

Publications

Using Machine-Learning Algorithms for Eutrophication Modeling: Case Study of Mar Menor Lagoon (Spain).

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