Dataset Information

Genetic and genomic characterization of vulva size traits in Yorkshire and Landrace gilts.

ABSTRACT: BACKGROUND:Reproductive performance is critical for efficient swine production. Recent results indicated that vulva size (VS) may be predictive of reproductive performance in sows. Study objectives were to estimate genetic parameters, identify genomic regions associated, and estimate genomic prediction accuracies (GPA) for VS traits. RESULTS:Heritability estimates of VS traits, vulva area (VA), height (VH), and width (VW) measurements, were moderately to highly heritable in Yorkshire, with 0.46?±?0.10, 0.55?±?0.10, 0.31?±?0.09, respectively, whereas these estimates were low to moderate in Landrace, with 0.16?±?0.09, 0.24?±?0.11, and 0.08?±?0.06, respectively. Genetic correlations within VS traits were very high for both breeds, with the lowest of 0.67?±?0.29 for VH and VW for Landrace. Genome-wide association studies (GWAS) for Landrace, reveled genomic region associated with VS traits on Sus scrofa chromosome (SSC) 2 (154-157?Mb), 7 (107-110?Mb), 8 (4-6?Mb), and 10 (8-19?Mb). For Yorkshire, genomic regions on SSC 1 (87-91 and 282-287?Mb) and 5 (67?Mb) were identified. All regions explained at least 3.4% of the genetic variance. Accuracies of genomic prediction were moderate in Landrace, ranging from 0.30 (VH) to 0.61 (VA), and lower for Yorkshire, with 0.07 (VW) to 0.11 (VH). Between-breed and multi-breed genomic prediction accuracies were low. CONCLUSIONS:Our findings suggest that VS traits are heritable in Landrace and Yorkshire gilts. Genomic analyses show that major QTL control these traits, and they differ between breed. Genomic information can be used to increase genetic gains for these traits in gilts. Additional research must be done to validate the GWAS and genomic prediction results reported in our study.

SUBMITTER: Corredor FA

PROVIDER: S-EPMC7068987 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Genetic and genomic characterization of vulva size traits in Yorkshire and Landrace gilts.

Corredor Flor-Anita FA Sanglard Leticia P LP Leach Richard J RJ Ross Jason W JW Keating Aileen F AF Serão Nick V L NVL

BMC genetics 20200312 1

<h4>Background</h4>Reproductive performance is critical for efficient swine production. Recent results indicated that vulva size (VS) may be predictive of reproductive performance in sows. Study objectives were to estimate genetic parameters, identify genomic regions associated, and estimate genomic prediction accuracies (GPA) for VS traits.<h4>Results</h4>Heritability estimates of VS traits, vulva area (VA), height (VH), and width (VW) measurements, were moderately to highly heritable in Yorksh ...[more]

PMID: 32164558

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Project description:BackgroundDue to ethical reasons, surgical castration of young male piglets in their first week of life without anesthesia will be banned in Germany from 2021. Breeding against boar taint is already implemented in sire breeds of breeding organizations but in recent years a low demand made this trait economically less important. The objective of this study was to estimate heritabilities and genetic relationships between boar taint compounds androstenone and skatole and maternal/paternal reproduction traits in 4'924 Landrace (LR) and 4'299 Large White (LW) animals from nucleus populations. Additionally, genome wide association analysis (GWAS) was performed per trait and breed to detect SNP marker with possible pleiotropic effects that are associated with boar taint and fertility.ResultsEstimated heritabilities (h2) were 0.48 (±0.08) for LR (0.39?±?0.07 for LW) for androstenone and 0.52 (±0.08) for LR (0.32?±?0.07 for LW) for skatole. Heritabilities for reproduction did not differ between breeds except age at first insemination (LR: h2?=?0.27 (±0.05), LW: h2?=?0.34 (±0.05)). Estimates of genetic correlation (rg) between boar taint and fertility were different in LR and LW breeds. In LR an unfavorable rg of 0.31 (±0.15) was observed between androstenone and number of piglets born alive, whereas this rg in LW (-?0.15 (±0.16)) had an opposite sign. A similar breed-specific difference is observed between skatole and sperm count. Within LR, the rg of 0.08 (±0.13) indicates no relationship between the traits, whereas the rg of -?0.37 (±0.14) in LW points to an unfavorable relationship. In LR GWAS identified QTL regions on SSC5 (21.1-22.3?Mb) for androstenone and on SSC6 (5.5-7.5?Mb) and SSC14 (141.1-141.6?Mb) for skatole. For LW, one marker was found on SSC17 at 48.1?Mb for androstenone and one QTL on SSC14 between 140.5?Mb and 141.6?Mb for skatole.ConclusionKnowledge about such genetic correlations could help to balance conventional breeding programs with boar taint in maternal breeds. QTL regions with unfavorable pleiotropic effects on boar taint and fertility could have deleterious consequences in genomic selection programs. Constraining the weighting of these QTL in the genomic selection formulae may be a useful strategy to avoid physiological imbalances.

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Dataset Information

Genetic and genomic characterization of vulva size traits in Yorkshire and Landrace gilts.

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Genetic and genomic characterization of vulva size traits in Yorkshire and Landrace gilts.

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