Ontology highlight
ABSTRACT:
SUBMITTER: Lo Giudice C
PROVIDER: S-EPMC7069340 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Lo Giudice Claudio C Silvestris Domenico Alessandro DA Roth Shalom Hillel SH Eisenberg Eli E Pesole Graziano G Gallo Angela A Picardi Ernesto E
Frontiers in genetics 20200306
Massive transcriptome sequencing through the RNAseq technology has enabled quantitative transcriptome-wide investigation of co-/post-transcriptional mechanisms such as alternative splicing and RNA editing. The latter is abundant in human transcriptomes in which million adenosines are deaminated into inosines by the ADAR enzymes. RNA editing modulates the innate immune response and its deregulation has been associated with different human diseases including autoimmune and inflammatory pathologies ...[more]