Mitogenome germline mutations and colorectal cancer risk in Polish population.

ABSTRACT:

Introduction

To date, several nuclear DNA variants have been shown to be associated with increased risk of developing colorectal cancer. Despite the fact that mitochondria play an important role in carcinogenesis, little is known about inherited mitochondrial DNA mutations that could be involved in this disease. Thus, potential associations between inherited mutations in the entire mitochondrial genomes and colorectal cancer were analysed in this study.

Material and methods

Two hundred mitogenome sequences determined for colorectal cancer patients and healthy individuals from Poland were used to investigate the association between mtDNA alleles or haplogroups and colorectal cancer. Additional mtDNA control region haplotypes determined for 1353 individuals from the general Po

SUBMITTER: Skonieczna K 

PROVIDER: S-EPMC7069428 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature