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Applications of variable-order fractional operators: a review.

ABSTRACT: Variable-order fractional operators were conceived and mathematically formalized only in recent years. The possibility of formulating evolutionary governing equations has led to the successful application of these operators to the modelling of complex real-world problems ranging from mechanics, to transport processes, to control theory, to biology. Variable-order fractional calculus (VO-FC) is a relatively less known branch of calculus that offers remarkable opportunities to simulate interdisciplinary processes. Recognizing this untapped potential, the scientific community has been intensively exploring applications of VO-FC to the modelling of engineering and physical systems. This review is intended to serve as a starting point for the reader interested in approaching this fascinating field. We provide a concise and comprehensive summary of the progress made in the development of VO-FC analytical and computational methods with application to the simulation of complex physical systems. More specifically, following a short introduction of the fundamental mathematical concepts, we present the topic of VO-FC from the point of view of practical applications in the context of scientific modelling.

SUBMITTER: Patnaik S

PROVIDER: S-EPMC7069480 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Applications of variable-order fractional operators: a review.

Patnaik Sansit S Hollkamp John P JP Semperlotti Fabio F

Proceedings. Mathematical, physical, and engineering sciences 20200212 2234

Variable-order fractional operators were conceived and mathematically formalized only in recent years. The possibility of formulating evolutionary governing equations has led to the successful application of these operators to the modelling of complex real-world problems ranging from mechanics, to transport processes, to control theory, to biology. Variable-order fractional calculus (VO-FC) is a relatively less known branch of calculus that offers remarkable opportunities to simulate interdiscip ...[more]

PMID: 32201475

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Project description:The mechanisms of atrial fibrillation (AF) are a challenging research topic. The rotor hypothesis states that the AF is sustained by a reentrant wave that propagates around an unexcited core. Cardiac tissue heterogeneities, both structural and cellular, play an important role during fibrillatory dynamics, so that the ionic characteristics of the currents, their spatial distribution and their structural heterogeneity determine the meandering of the rotor. Several studies about rotor dynamics implement the standard diffusion equation. However, this mathematical scheme carries some limitations. It assumes the myocardium as a continuous medium, ignoring, therefore, its discrete and heterogeneous aspects. A computational model integrating both, electrical and structural properties could complement experimental and clinical results. A new mathematical model of the action potential propagation, based on complex fractional order derivatives is presented. The complex derivative order appears of considering the myocardium as discrete-scale invariant fractal. The main aim is to study the role of a myocardial, with fractal characteristics, on atrial fibrillatory dynamics. For this purpose, the degree of structural heterogeneity is described through derivatives of complex order ? = ? + j?. A set of variations for ? is tested. The real part ? takes values ranging from 1.1 to 2 and the imaginary part ? from 0 to 0.28. Under this scheme, the standard diffusion is recovered when ? = 2 and ? = 0. The effect of ? on the action potential propagation over an atrial strand is investigated. Rotors are generated in a 2D model of atrial tissue under electrical remodeling due to chronic AF. The results show that the degree of structural heterogeneity, given by ?, modulates the electrophysiological properties and the dynamics of rotor-type reentrant mechanisms. The spatial stability of the rotor and the area of its unexcited core are modulated. As the real part decreases and the imaginary part increases, simulating a higher structural heterogeneity, the vulnerable window to reentrant is increased, as the total meandering of the rotor tip. This in silico study suggests that structural heterogeneity, described by means of complex order derivatives, modulates the stability of rotors and that a wide range of rotor dynamics can be generated.

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Applications of variable-order fractional operators: a review.

Publications

Applications of variable-order fractional operators: a review.

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