Ontology highlight
ABSTRACT:
SUBMITTER: Mastromarino M
PROVIDER: S-EPMC7069519 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Mastromarino Margherita M Kirpotina Liliya N LN Schepetkin Igor A IA Quinn Mark T MT Lacivita Enza E Leopoldo Marcello M
MedChemComm 20191007 12
Formyl peptide receptor 1 (FPR1) is expressed on a variety of immune system cells and is a key regulator of the inflammatory environment. Therefore, the development of FPR1 antagonists may represent a novel approach for modulating innate immunity and treating inflammatory diseases. Starting from a dipeptide scaffold that is structurally related to the natural product aurantiamide, we investigated the structure-activity relationships of the dipeptide (2<i>R</i>,2'<i>S</i>)-<b>6</b>, which was rep ...[more]