Ontology highlight
ABSTRACT:
SUBMITTER: Boon R
PROVIDER: S-EPMC7069944 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Nature communications 20200313 1
Predicting drug-induced liver injury in a preclinical setting remains challenging, as cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived hepatocyte-like cells (HLCs), and hepatoma cells exhibit poor drug biotransformation capacity. We here demonstrate that hepatic functionality depends more on cellular metabolism and extracellular nutrients than on developmental regulators. Specifically, we demonstrate that increasing extracellular amino acids beyond the nutritional need of ...[more]