Minocycline-induced microbiome alterations predict cafeteria diet-induced spatial recognition memory impairments in rats.

ABSTRACT: Diets rich in sugar and saturated fat are associated with cognitive impairments in both humans and rodents with several potential mechanisms proposed. To test the involvement of diet-induced pro-inflammatory signaling, we exposed rats to a high-fat, high-sugar cafeteria diet, and administered the anti-inflammatory antibiotic minocycline. In the first experiment minocycline was coadministered across the diet, then in a second, independent cohort it was introduced following 4 weeks of cafeteria diet. Cafeteria diet impaired novel place recognition memory throughout the study. Minocycline not only prevented impairment in spatial recognition memory but also reversed impairment established in rats following 4 weeks cafeteria diet. Further, minocycline normalized diet-induced increases in hippoc

SUBMITTER: Leigh SJ 

PROVIDER: S-EPMC7069973 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature