Unknown

Dataset Information

0

"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis.


ABSTRACT: Exposure to nanomaterials (NMs) is an emerging threat to human health, and the understanding of their intracellular behavior and related toxic effects is urgently needed. Ferroptosis is a newly discovered, iron-mediated cell death that is distinctive from apoptosis or other cell-death pathways. No evidence currently exists for the effect of "iron free" engineered NMs on ferroptosis. We showed by several approaches that (1) zinc oxide nanoparticles (ZnO NPs)-induced cell death involves ferroptosis; (2) ZnO NPs-triggered ferroptosis is associated with elevation of reactive oxygen species (ROS) and lipid peroxidation, along with depletion of glutathione (GSH) and downregulation of glutathione peroxidase 4 (GPx4); (3) ZnO NPs disrupt intracellular iron homeostasis by orchestrating iron uptake, storage and export; (4) p53 largely participates in ZnO NPs-induced ferroptosis; and (5) ZnO particle remnants and dissolved zinc ion both contribute to ferroptosis. In conclusion, our data provide a new mechanistic rationale for ferroptosis as a novel cell-death phenotype induced by engineered NMs.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7070056 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

altmetric image

Publications

"Iron free" zinc oxide nanoparticles with ion-leaking properties disrupt intracellular ROS and iron homeostasis to induce ferroptosis.

Zhang Changping C   Liu Zixuan Z   Zhang Yuhao Y   Ma Liang L   Song Erqun E   Song Yang Y  

Cell death & disease 20200313 3


Exposure to nanomaterials (NMs) is an emerging threat to human health, and the understanding of their intracellular behavior and related toxic effects is urgently needed. Ferroptosis is a newly discovered, iron-mediated cell death that is distinctive from apoptosis or other cell-death pathways. No evidence currently exists for the effect of "iron free" engineered NMs on ferroptosis. We showed by several approaches that (1) zinc oxide nanoparticles (ZnO NPs)-induced cell death involves ferroptosi  ...[more]

Similar Datasets

| S-EPMC6817894 | biostudies-other
| S-EPMC10281259 | biostudies-literature
| S-EPMC8566589 | biostudies-literature
| S-EPMC4829717 | biostudies-literature
| S-EPMC8299017 | biostudies-literature
| S-EPMC9891695 | biostudies-literature
| S-EPMC10572259 | biostudies-literature
| S-EPMC5919926 | biostudies-literature
| S-EPMC7205875 | biostudies-literature
| S-EPMC10708329 | biostudies-literature