Dichloromethylation of enones by carbon nitride photocatalysis.

ABSTRACT: Small organic radicals are ubiquitous intermediates in photocatalysis and are used in organic synthesis to install functional groups and to tune electronic properties and pharmacokinetic parameters of the final molecule. Development of new methods to generate small organic radicals with added functionality can further extend the utility of photocatalysis for synthetic needs. Herein, we present a method to generate dichloromethyl radicals from chloroform using a heterogeneous potassium poly(heptazine imide) (K-PHI) photocatalyst under visible light irradiation for C1-extension of the enone backbone. The method is applied on 15 enones, with γ,γ-dichloroketones yields of 18-89%. Due to negative zeta-potential (-40 mV) and small particle size (100 nm) K-PHI suspension is used in quasi-homogene

SUBMITTER: Mazzanti S 

PROVIDER: S-EPMC7070069 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature