Ontology highlight
ABSTRACT:
SUBMITTER: Mukhtar T
PROVIDER: S-EPMC7070074 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Mukhtar Tanzila T Breda Jeremie J Grison Alice A Karimaddini Zahra Z Grobecker Pascal P Iber Dagmar D Beisel Christian C van Nimwegen Erik E Taylor Verdon V
Scientific reports 20200313 1
Neural stem cells (NSCs) generate neurons of the cerebral cortex with distinct morphologies and functions. How specific neuron production, differentiation and migration are orchestrated is unclear. Hippo signaling regulates gene expression through Tead transcription factors (TFs). We show that Hippo transcriptional coactivators Yap1/Taz and the Teads have distinct functions during cortical development. Yap1/Taz promote NSC maintenance and Satb2<sup>+</sup> neuron production at the expense of Tbr ...[more]