Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.
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ABSTRACT:
SUBMITTER: Del Carmen S
PROVIDER: S-EPMC7070091 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Prognostic implications of EGFR protein expression in sporadic colorectal tumors: Correlation with copy number status, mRNA levels and miRNA regulation.
Del Carmen Sofía S Corchete Luís Antonio LA Gervas Ruth R Rodriguez Alba A Garcia María M Álcazar José Antonio JA García Jacinto J Bengoechea Oscar O Muñoz-Bellvis Luis L Sayagués José María JM Abad Mar M
Scientific reports 20200313 1
Sporadic colorectal cancer (sCRC) is the third most frequent cancer worldwide and the second most common cause of cancer-related deaths (mainly due metastatic dissemination). We investigated the immunohistochemical expression of frequently altered proteins in primary tumors from 51 patients (25 liver metastatic and 26 non-metastatic cases) with a median 103 months follow-up (103 months). We evaluated EGFR copy number (using SNP arrays and FISH) and its expression and regulation (by mRNA and miRN ...[more]
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