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ABSTRACT: Importance
Impulsivity during periods of abstinence is a critical symptom of patients who use methamphetamine (MA).Objective
To evaluate changes in impulse inhibition elicited by repetitive transcranial magnetic stimulation (rTMS) in patients with MA addiction.Design, setting, and participants
This randomized clinical trial was conducted in Da Lian Shan Addiction Rehabilitation Center, Nanjing, China, from December 1, 2018, to April 20, 2019. Effects of the intervention were examined at 3 time points: after a single session (day 1), 24 hours after 10 repeated sessions (day 11), and at 3 weeks of follow-up (day 31). Men with MA addiction and healthy male control participants were recruited for this study. Data analysis was performed from March 2019 to October 2019.Interventions
Patients who use MA were randomized to undergo sham rTMS (36 patients) and or 1-Hz rTMS (37 patients) to the left prefrontal cortex, receiving daily TMS treatments for 10 consecutive days.Main outcomes and measures
The primary outcome was impulse inhibition, which is primarily embodied by accuracy reduction (ie, accuracy cost) from standard to deviant trials in a 2-choice oddball task (80% standard and 20% deviant trials).Result
The study included 73 men with MA addiction (mean [SD] age, 38.49 [7.69] years) and 33 male healthy control participants without MA addiction (mean [SD] age, 35.15 [9.68] years). The mean (SD) duration of abstinence for the men with MA addiction was 9.27 (4.61) months. Compared with the control group, patients with MA addiction exhibited greater impulsivity (accuracy cost, 3.3% vs 6.2%). The single session of 1-Hz rTMS over the left prefrontal cortex significantly increased accuracy from 91.4% to 95.7% (F1,36?=?9.58; P?Conclusions and relevanceThese findings suggest that repeated rTMS sessions have sustained effects on impulse inhibition in patients with MA addiction and provide novel data on impulsivity management strategies for addiction rehabilitation.Trial registration
ChiCTR-ROC-16008541.
SUBMITTER: Yuan J
PROVIDER: S-EPMC7070234 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Yuan Jiajin J Liu Weijun W Liang Qiongdan Q Cao Xinyu X Lucas Molly V MV Yuan Ti-Fei TF
JAMA network open 20200302 3
<h4>Importance</h4>Impulsivity during periods of abstinence is a critical symptom of patients who use methamphetamine (MA).<h4>Objective</h4>To evaluate changes in impulse inhibition elicited by repetitive transcranial magnetic stimulation (rTMS) in patients with MA addiction.<h4>Design, setting, and participants</h4>This randomized clinical trial was conducted in Da Lian Shan Addiction Rehabilitation Center, Nanjing, China, from December 1, 2018, to April 20, 2019. Effects of the intervention w ...[more]