Ontology highlight
ABSTRACT:
SUBMITTER: Scodeller P
PROVIDER: S-EPMC7070747 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Scodeller Pablo P Asciutto Eliana K EK
Molecules (Basel, Switzerland) 20200213 4
To penetrate solid tumors, low molecular weight (Mw < 10 KDa) compounds have an edge over antibodies: their higher penetration because of their small size. Because of the dense stroma and high interstitial fluid pressure of solid tumors, the penetration of higher Mw compounds is unfavored and being small thus becomes an advantage. This review covers a wide range of peptidic ligands-linear, cyclic, macrocyclic and cyclotidic peptides-to target tumors: We describe the main tools to identify peptid ...[more]