Dataset Information

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study.

ABSTRACT: In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21-50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (n = 44). From the food diary, we calculated the proportions of the total energy and macronutrients consumed in the morning and evening, and the clock time at which 25%, 50% and 75% of total energy was consumed. A greater proportion of energy intake in the morning was significantly associated with higher insulin sensitivity estimated by Matsuda Index (B = 2.8 per 10%; 95%CI: 0.3, 5.2). The time at which 25% of energy was consumed was associated with insulin sensitivity estimated by Matsuda Index (B = -1.6 per hour; 95%CI: -3.0, -0.3) and QUICKI (B = -1.4 per hour, 95%CI: -2.8, -0.1). The timing of carbohydrate consumption demonstrated similar associations. Greater energy intake earlier in the day was associated with higher insulin sensitivity in individuals without diabetes.

SUBMITTER: Rangaraj VR

PROVIDER: S-EPMC7071301 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study.

Rangaraj Vittobai Rashika VR Siddula Alankrita A Burgess Helen J HJ Pannain Silvana S Knutson Kristen L KL

Nutrients 20200216 2

In addition to the caloric and macronutrient composition of meals, timing of energy consumption may be important for optimal glucose metabolism. Our goal was to examine whether the habitual timing of energy intake was associated with insulin sensitivity in healthy volunteers. Volunteers without diabetes aged 21-50 years completed a 3-day food diary and underwent an oral glucose tolerance test to estimate insulin sensitivity (<i>n</i> = 44). From the food diary, we calculated the proportions of t ...[more]

PMID: 32079066

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Project description:Background:The evidence on the impact of high sugar consumption on micronutrient dilution does not yet allow for the establishment of clear thresholds of consumption. To establish upper and lower limit intake thresholds for added sugar, more studies from different countries and multiple populations are needed. The aim of this study was to examine the association between the intakes of added sugar and various micronutrients among the adult Swedish population across almost two decades. Methods:The data were obtained from the samples from two populations: 1) Riksmaten Adults, a national dietary survey (n?=?1797, 44% male, aged 18-80?years, data collection from 2010 to 11) that assessed dietary intake using a 4-day web-based food diary; and 2) the Malmö Diet and Cancer Study, a population-based cohort study (n?=?12,238, 45% male, aged 45-68?years, data collection from 1991 to 1994) that assessed dietary intake via a combination of a 7-day food diary, a food frequency questionnaire and an interview. The mean daily intake of nine micronutrients (calcium, folate, iron, magnesium, potassium, selenium, vitamin C, vitamin D, and zinc), adjusted for age, sex, BMI and energy intake, were examined across six added-sugar-intake groups (<?5%E, 5-7.5%E, 7.5-10%E, 10-15%E, 15-20%E, and?>? 20%E). Results:We observed significant inverse associations between the intake of added sugar and the intake of all micronutrients in both populations. The associations were linear; however, we could not determine the threshold of added sugar intake beyond which the micronutrient intake was clearly compromised. Conclusions:These findings suggest that in two Swedish populations the higher the intake of added sugar in the diet, the more likely it is that the intake of micronutrients will be compromised, in two Swedish populations. However, although the trends are significant and consistent with those obtained in other studies on the subject, future studies are needed in order to build the necessary scientific knowledge to establish a threshold of added sugar intake based on micronutrient dilution.

Dataset Information

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study.

Publications

Association between Timing of Energy Intake and Insulin Sensitivity: A Cross-Sectional Study.

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