ABCA7-A Member of the ABC Transporter Family in Healthy and Ailing Brain.
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ABSTRACT:
SUBMITTER: Surguchev AA
PROVIDER: S-EPMC7071517 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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ABCA7-A Member of the ABC Transporter Family in Healthy and Ailing Brain.
Surguchev Alexei A AA Surguchov Andrei A
Brain sciences 20200222 2
Identification of genetic markers of a human disease, which is generally sporadic, may become an essential tool for the investigation of its molecular mechanisms. The role of ABCA7 in Alzheimer's disease (AD) was discovered less than ten years ago when meta-analyses provided evidence that rs3764650 is a new AD susceptibility locus. Recent research advances in this locus and new evidence regarding ABCA7 contribution to the AD pathogenesis brought a new understanding of the underlying mechanisms o ...[more]
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