Ontology highlight
ABSTRACT:
SUBMITTER: Tam HK
PROVIDER: S-EPMC7071731 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Tam Heng-Keat HK Malviya Viveka N VN Foong Wuen-Ee WE Herrmann Andrea A Malloci Giuliano G Ruggerone Paolo P Vargiu Attilio V AV Pos Klaas M KM
Journal of molecular biology 20191225 4
AcrAB(Z)-TolC is the main drug efflux transporter complex in Escherichia coli. The extrusion of various toxic compounds depends on several drug binding sites within the trimeric AcrB transporter. Membrane-localized carboxylated substrates, such as fusidic acid and hydrophobic β-lactams, access the pump via a groove between the transmembrane helices TM1 and TM2. In this article, the transport route from the initial TM1/TM2 groove binding site toward the deep binding pocket located in the periplas ...[more]