Ontology highlight
ABSTRACT:
SUBMITTER: Goel RR
PROVIDER: S-EPMC7071891 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Goel Rishi R RR Wang Xinghao X O'Neil Liam J LJ Nakabo Shuichiro S Hasneen Kowser K Gupta Sarthak S Wigerblad Gustaf G Blanco Luz P LP Kopp Jeffrey B JB Morasso Maria I MI Kotenko Sergei V SV Yu Zu-Xi ZX Carmona-Rivera Carmelo C Kaplan Mariana J MJ
Proceedings of the National Academy of Sciences of the United States of America 20200224 10
Type III IFN lambdas (IFN-λ) have recently been described as important mediators of immune responses at barrier surfaces. However, their role in autoimmune diseases such as systemic lupus erythematosus (SLE), a condition characterized by aberrant type I IFN signaling, has not been determined. Here, we identify a nonredundant role for IFN-λ in immune dysregulation and tissue inflammation in a model of TLR7-induced lupus. IFN-λ protein is increased in murine lupus and IFN-λ receptor (Ifnlr1) defic ...[more]