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Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.

ABSTRACT: Objective:To explore the correlation between the spectral computed tomography (CT) imaging parameters and the Ki-67 labeling index in lung adenocarcinoma. Methods:Spectral CT imaging parameters [iodine concentrations of lesions (ICLs) in the arterial phase (ICLa) and venous phase (ICLv), normalized IC in the aorta (NICa/NICv), slope of the spectral HU curve (?HUa/?HUv) and monochromatic CT number enhancement on 40 keV and 70 keV images (CT40keVa/v, CT70keVa/v)] in 34 lung adenocarcinomas were analyzed, and common molecular markers, including the Ki-67 labeling index, were detected with immunohistochemistry. Different Ki-67 labeling indexes were measured and grouped into four grades according to the number of positive-stained cells (grade 0, ?1%; 1%30%). One-way analysis of variance (ANOVA) was used to compare the four different grades, and the Bonferroni method was used to correct the P value for multiple comparisons. A Spearman correlation analysis was performed to further research a quantitative correlation between the Ki-67 labeling index and spectral CT imaging parameters. Results:CT40keVa, CT40keVv, CT70keVa and CT70keVv increased as the grade increased, and CT70keVa and CT70keVv were statistically significant (P<0.05). These four parameters and the Ki-67 labeling index showed a moderate positive correlation with lung adenocarcinoma nodules. ICL, NIC and ?HU in the arterial and venous phases were not significantly different among the four grades. Conclusions:The spectral CT imaging parameters CT40keVa, CT40keVv, CT70keVa and CT70keVv gradually increased with Ki-67 expression and showed a moderate positive correlation with lung adenocarcinomas. Therefore, spectral CT imaging parameter-enhanced monochromatic CT numbers at 70 keV may indicate the extent of proliferation of lung adenocarcinomas.

SUBMITTER: Chen M

PROVIDER: S-EPMC7072011 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature

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Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.

Chen Mailin M Li Xiaoting X Wei Yiyuan Y Qi Liping L Sun Ying-Shi YS

Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 20200201 1

<h4>Objective</h4>To explore the correlation between the spectral computed tomography (CT) imaging parameters and the Ki-67 labeling index in lung adenocarcinoma.<h4>Methods</h4>Spectral CT imaging parameters [iodine concentrations of lesions (ICLs) in the arterial phase (ICLa) and venous phase (ICLv), normalized IC in the aorta (NICa/NICv), slope of the spectral HU curve (λHUa/λHUv) and monochromatic CT number enhancement on 40 keV and 70 keV images (CT40keVa/v, CT70keVa/v)] in 34 lung adenocar ...[more]

PMID: 32194309

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Project description:PurposeTo investigate whether preoperative histogram parameters of dynamic contrast-enhanced MRI (DCE-MRI) can assess the expression of Ki-67 in prostate cancer (PCa).Materials and methodsA consecutive series of 76 patients with pathology-proven PCa who underwent routine DCE-MRI scans were retrospectively recruited. Quantitative parameters including the volume transfer constant (Ktrans ), rate contrast (Kep ), extracellular-extravascular volume fraction (Ve ), and plasma volume (Vp ) by outlining the three-dimensional volume of interest (VOI) of all lesions were processed. Then, the histogram analyses of these quantitative parameters were performed. The Spearman rank correlation analysis was used to evaluate the correlation of these parameters and Ki-67 expression of PCa. Receiver operating characteristic (ROC) curve analysis was adopted to evaluate the efficacy of these quantitative histogram parameters in identifying high Ki-67 expression from low Ki-67 expression of PCa.ResultsEighty-eight PCa lesions were enrolled in this study, including 31 lesions with high Ki-67 expression and 57 lesions with low Ki-67 expression. The median, mean, 75th percentile, and 90th percentile derived from Ktrans and Kep had a moderately positive correlation with Ki-67 expression (r = 0.361-0.450, p < 0.05), in which both the median and mean of Ktrans had the highest positive correlation (r = 0.450, p < 0.05). The diagnostic efficacy of the Ktrans median, mean, 75th percentile, and 90th percentile, along with the Kep -based median and mean was assessed by the ROC curve. The area under the curve (AUC) of the mean for Ktrans was the highest (0.826). When the cut-off of the mean for Ktrans was ≥0.47/min, its Youden index, sensitivity, and specificity were 0.625, 0.871, and 0.754, respectively. The AUC of the median of Kep was the lowest (0.772).ConclusionThe histogram of DCE-MRI quantitative parameters is correlated with Ki-67 expression, which has the potential to noninvasively assess the expression of Ki-67 with patients of PCa.

Dataset Information

Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.

Publications

Spectral CT imaging parameters and Ki-67 labeling index in lung adenocarcinoma.

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