The Mitochondrial Lon Protease: Novel Functions off the Beaten Track?
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ABSTRACT:
SUBMITTER: Voos W
PROVIDER: S-EPMC7072132 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
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The Mitochondrial Lon Protease: Novel Functions off the Beaten Track?
Voos Wolfgang W Pollecker Karen K
Biomolecules 20200207 2
To maintain organellar function, mitochondria contain an elaborate endogenous protein quality control system. As one of the two soluble energy-dependent proteolytic enzymes in the matrix compartment, the protease Lon is a major component of this system, responsible for the degradation of misfolded proteins, in particular under oxidative stress conditions. Lon defects have been shown to negatively affect energy production by oxidative phosphorylation but also mitochondrial gene expression. In thi ...[more]
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