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Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease.

ABSTRACT: Parkinson's disease (PD) is one of the main neurodegenerative disease characterized by a progressive degeneration of neurons constituted by dopamine in the substantia nigra pars compacta. The etiologies of PD remain unclear. Aging is the main risk factor for PD. Aging could dysregulate molecular pathways controlling cell homeostatic mechanisms. PD cells are the sites of several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures are driven by circadian rhythms. Biologic rhythms are complex systems interacting with the environment and controlling several physiological pathways. Recent findings have shown that the dysregulation of the circadian rhythms is correlated with PD and its metabolic dysregulations. This review is focused on the key role of circadian rhythms and their impact on neuroinflammation and oxidative stress in Parkinson's disease.

SUBMITTER: Vallee A

PROVIDER: S-EPMC7072287 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature

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Circadian rhythms, Neuroinflammation and Oxidative Stress in the Story of Parkinson's Disease.

Vallée Alexandre A Lecarpentier Yves Y Guillevin Rémy R Vallée Jean-Noël JN

Cells 20200128 2

Parkinson's disease (PD) is one of the main neurodegenerative disease characterized by a progressive degeneration of neurons constituted by dopamine in the substantia nigra pars compacta. The etiologies of PD remain unclear. Aging is the main risk factor for PD. Aging could dysregulate molecular pathways controlling cell homeostatic mechanisms. PD cells are the sites of several metabolic abnormalities including neuroinflammation and oxidative stress. Metabolic structures are driven by circadian ...[more]

PMID: 32012898

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