MTOR Regulation of Metabolism in Hematologic Malignancies.
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ABSTRACT:
SUBMITTER: Mirabilii S
PROVIDER: S-EPMC7072383 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Publications
mTOR Regulation of Metabolism in Hematologic Malignancies.
Mirabilii Simone S Ricciardi Maria Rosaria MR Tafuri Agostino A
Cells 20200211 2
Neoplastic cells rewire their metabolism, acquiring a selective advantage over normal cells and a protection from therapeutic agents. The mammalian Target of Rapamycin (mTOR) is a serine/threonine kinase involved in a variety of cellular activities, including the control of metabolic processes. mTOR is hyperactivated in a large number of tumor types, and among them, in many hematologic malignancies. In this article, we summarized the evidence from the literature that describes a central role for ...[more]
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