Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC7072390 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Liu Yang Y Pang Ying Y Caisova Veronika V Ding Jianyi J Yu Di D Zhou Yiqiang Y Huynh Thanh-Truc TT Ghayee Hans H Pacak Karel K Yang Chunzhang C
Cancers 20200123 2
Succinate dehydrogenase subunit B (SDHB) deficiency frequently occurs in cluster I pheochromocytomas and paragangliomas (PCPGs). <i>SDHB</i>-mutated PCPGs are characterized by alterations in the electron transport chain, metabolic reprogramming of the tricarboxylic cycle, and elevated levels of reactive oxygen species (ROS). We discovered that <i>SDHB-</i>deficient PCPG cells exhibit increased oxidative stress burden, which leads to elevated demands for glutathione metabolism. Mechanistically, n ...[more]