Ontology highlight
ABSTRACT:
SUBMITTER: Richter GHS
PROVIDER: S-EPMC7072515 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Richter Günther H S GHS Hensel Tim T Schmidt Oxana O Saratov Vadim V von Heyking Kristina K Becker-Dettling Fiona F Prexler Carolin C Yen Hsi-Yu HY Steiger Katja K Fulda Simone S Dirksen Uta U Weichert Wilko W Wang Shudong S Burdach Stefan S Schäfer Beat W BW
Cancers 20200128 2
<h4>Background</h4>Previously, we used inhibitors blocking BET bromodomain binding proteins (BRDs) in Ewing sarcoma (EwS) and observed that long term treatment resulted in the development of resistance. Here, we analyze the possible interaction of BRD4 with cyclin-dependent kinase (CDK) 9.<h4>Methods</h4>Co-immunoprecipitation experiments (CoIP) to characterize BRD4 interaction and functional consequences of inhibiting transcriptional elongation were assessed using drugs targeting of BRD4 or CDK ...[more]