Beyond Tumor Suppression: Senescence in Cancer Stemness and Tumor Dormancy.

ABSTRACT: Here, we provide an overview of the importance of cellular fate in cancer as a group of diseases of abnormal cell growth. Tumor development and progression is a highly dynamic process, with several phases of evolution. The existing evidence about the origin and consequences of cancer cell fate specification (e.g., proliferation, senescence, stemness, dormancy, quiescence, and cell cycle re-entry) in the context of tumor formation and metastasis is discussed. The interplay between these dynamic tumor cell phenotypes, the microenvironment, and the immune system is also reviewed in relation to cancer. We focus on the role of senescence during cancer progression, with a special emphasis on its relationship with stemness and dormancy. Selective interventions on senescence and dormancy cell fate

SUBMITTER: Triana-Martinez F 

PROVIDER: S-EPMC7072600 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature