Ontology highlight
ABSTRACT:
SUBMITTER: Melnik D
PROVIDER: S-EPMC7072698 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Melnik Daniela D Sahana Jayashree J Corydon Thomas J TJ Kopp Sascha S Nassef Mohamed Zakaria MZ Wehland Markus M Infanger Manfred M Grimm Daniela D Krüger Marcus M
Cells 20200205 2
Detachment and the formation of spheroids under microgravity conditions can be observed with various types of intrinsically adherent human cells. In particular, for cancer cells this process mimics metastasis and may provide insights into cancer biology and progression that can be used to identify new drug/target combinations for future therapies. By using the synthetic glucocorticoid dexamethasone (DEX), we were able to suppress spheroid formation in a culture of follicular thyroid cancer (FTC) ...[more]