Ontology highlight
ABSTRACT:
SUBMITTER: Wai KC
PROVIDER: S-EPMC7072739 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Wai Katherine C KC Strohl Madeleine P MP van Zante Annemieke A Ha Patrick K PK
Cells 20200222 2
The incidence of human papillomavirus (HPV)-related head and neck squamous cell carcinoma continues to increase. Accurate diagnosis of the HPV status of a tumor is vital, as HPV+ versus HPV- tumors represent two unique biological and clinical entities with different treatment strategies. High-risk HPV subtypes encode oncoproteins E6 and E7 that disrupt cellular senescence and ultimately drive tumorigenesis. Current methods for detection of HPV take advantage of this established oncogenic pathway ...[more]