Ontology highlight
ABSTRACT:
SUBMITTER: Ignat SR
PROVIDER: S-EPMC7072785 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Ignat Simona-Rebeca SR Dinescu Sorina S Hermenean Anca A Costache Marieta M
Cells 20200218 2
Inflammation has been known to be an important driver of fibrogenesis in the liver and onset of hepatic fibrosis. It starts off as a process meant to protect the liver from further damage, but it can become the main promoter of liver fibrosis. There are many inflammation-related pathways activated during liver fibrosis that lead to hepatic stellate cells (HSCs) activation and collagen-deposition in the liver. Such events are mostly modulated upstream of HSCs and involve signals from hepatocytes ...[more]